Step 1
Medical intake
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A few minutes
Topical retinoids act on the earliest step in acne — the plugged follicle — which is why dermatology guidelines position them as the foundation of most acne regimens rather than an add-on.
Acne Clear (Tretinoin)
Compounded Tretinoin Topical
$99/mo*
Duration
A topical retinoid that supports faster skin cell turnover and helps keep pores from clogging. Compounded so the strength and base can be matched to your skin rather than pulled off a shelf.
Supports
Get Started
AcneSkin cell turnoverPore health
HSA/FSA reimbursable
No Membership Required
Licensed US Pharmacies
Compounded tretinoin is not FDA-approved. Increases sun sensitivity; daily broad-spectrum SPF is part of the protocol. Prescription only; dispensed after medical evaluation.
Fast, discreet shipping
Unlimited follow-up with licensed physicians
Topical retinoids act on the earliest step in acne — the plugged follicle — which is why dermatology guidelines position them as the foundation of most acne regimens rather than an add-on.
WHY RETINOIDS
Acne starts before the pimple. Retinoids work upstream.
Zaenglein et al., Journal of the American Academy of Dermatology (2016)
Inflammatory lesions
Comedonal lesions
Illustrative of the treatment course described in dermatology guidance. Not trial data and not a prediction of individual results.
HOW TRETINOIN WORKS
Keeps pores from clogging in the first place.
Glucose control.
Tretinoin is a vitamin A derivative that binds retinoic acid receptors in skin cells. Activating those receptors changes how quickly cells turn over and how readily they shed, which addresses the follicular plug at the root of acne rather than the inflammation downstream of it.
Speeds cell turnover
Tretinoin accelerates how quickly skin cells at the follicle wall mature and shed, so dead cells are less likely to accumulate and plug the pore.
Reduces new comedones
By keeping the follicle clear, tretinoin limits formation of the microcomedones that later become whiteheads, blackheads, and inflamed lesions.
Supports skin texture over time
Sustained retinoid use has been studied for its effects on collagen production and pigment distribution, which is why improvements in tone and texture are often reported alongside acne clearance.
Works best with sun protection
Retinoids increase sun sensitivity. Daily broad-spectrum SPF is part of the protocol, not an optional extra.
HOW PEPTRA WORKS
From intake to your door in three to seven days
Prescription medicine from board-certified physicians, shipped to your door.
Step 2
Doctor review
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*
Within 72 hours
Step 3
Fast shipping
Approved medications ship directly to your door in discreet packaging.
2-5 business days
Step 4
Unlimited messaging
Your doctor is available via chat any time for additional support. Video consults available.
Up to 12 months
Prescription medicine from board-certified physicians, shipped to your door.
*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
WHY PEPTRA MEDICINE
Precision medicine protocols to support longevity
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Proactive care
Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.
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Transparent pricing
No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.
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Board-certified doctors
Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.
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Curated by longevity experts
Every protocol is built by medical experts, based on longevity research from Our founder's science team.
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COMMON QUESTIONS
Questions, answered
What is compounded tretinoin?
How long until I see results?
What are the side effects?
Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program.