Step 1
Medical intake
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A few minutes
In a large case-control study, women using transdermal estrogen showed a venous thromboembolism risk close to non-users, while oral estrogen users showed a meaningfully higher risk — the route of administration was the variable.
Estradiol Cream
Estradiol Topical Cream
$99/mo*
Duration
Estradiol applied to the skin instead of swallowed. Absorbing through the skin skips the first pass through the liver, which changes how the body processes it.
Supports
Get Started
Hot flashesNight sweatsMenopausal symptom relief
HSA/FSA reimbursable
No Membership Required
Licensed US Pharmacies
Hormone therapy carries important risks including cardiovascular events and certain cancers. Prescribed at the lowest effective dose for the shortest appropriate duration. Prescription only.
Fast, discreet shipping
Unlimited follow-up with licensed physicians
In a large case-control study, women using transdermal estrogen showed a venous thromboembolism risk close to non-users, while oral estrogen users showed a meaningfully higher risk — the route of administration was the variable.
ROUTE MATTERS
Through the skin, the liver never sees the first pass.
Canonico et al., ESTHER Study, Circulation (2007)
Observational study data. Describes a difference between administration routes; not a safety claim for any specific product.
HOW TOPICAL ESTRADIOL WORKS
Same hormone, different route in.
Glucose control.
Topical estradiol delivers the same molecule as the tablet, absorbed through skin into circulation rather than through the digestive tract. Because it does not pass through the liver before reaching the bloodstream, the downstream effects on liver-produced proteins differ from oral dosing.
Skips first-pass metabolism
Absorption through skin means estradiol reaches circulation without being processed by the liver first, which changes its effect on clotting factors and binding proteins.
Steady daily levels
Daily topical application produces more consistent blood levels than the peak-and-fall pattern of once-daily oral dosing.
Dose adjusted by measurement
Absorption through skin varies between individuals. Levels are checked and the applied amount adjusted rather than assumed.
Application site care
Apply to clean, dry skin and let it absorb fully. Avoid skin-to-skin contact at the application site with partners or children until absorbed.
HOW PEPTRA WORKS
From intake to your door in three to seven days
Prescription medicine from board-certified physicians, shipped to your door.
Step 2
Doctor review
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*
Within 72 hours
Step 3
Fast shipping
Approved medications ship directly to your door in discreet packaging.
2-5 business days
Step 4
Unlimited messaging
Your doctor is available via chat any time for additional support. Video consults available.
Up to 12 months
Prescription medicine from board-certified physicians, shipped to your door.
*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
WHY PEPTRA MEDICINE
Precision medicine protocols to support longevity
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Proactive care
Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.
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Transparent pricing
No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.
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Board-certified doctors
Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.
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Curated by longevity experts
Every protocol is built by medical experts, based on longevity research from Our founder's science team.
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COMMON QUESTIONS
Questions, answered
What is estradiol cream?
What are the risks of hormone therapy?
Do I need progesterone too?
Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program.