Step 1
Medical intake
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A few minutes
Randomized data show that estradiol started early in menopause slowed the progression of atherosclerosis, while the same therapy started ten or more years out did not — the window, not the hormone, drove the difference.
Estradiol Oral Tablet
Estradiol Oral Tablet
$59/mo*
Duration
The primary estrogen the ovaries stop producing at menopause. Replacing it is the most studied approach to hot flashes, night sweats, and vaginal dryness, and the timing of when you start matters.
Supports
Menopausal symptom relief
HSA/FSA reimbursable
No Membership Required
Licensed US Pharmacies
Hormone therapy carries important risks including cardiovascular events and certain cancers. Prescribed at the lowest effective dose for the shortest appropriate duration. Prescription only.
Fast, discreet shipping
Unlimited follow-up with licensed physicians
Randomized data show that estradiol started early in menopause slowed the progression of atherosclerosis, while the same therapy started ten or more years out did not — the window, not the hormone, drove the difference.
THE TIMING WINDOW
The same hormone, ten years apart, is not the same decision.
Manson et al., JAMA (2017); Hodis et al., ELITE, NEJM (2016)
Risk-benefit profile
Risk-benefit profile
Illustrative of the timing relationship described in the cited analyses. Not a prediction for any individual.
HOW ESTRADIOL WORKS
Restores the signal your body stopped sending.
Glucose control.
Estradiol is bioidentical to the estrogen the ovaries produce. Estrogen receptors sit throughout the body — in the brain's temperature center, in bone, in vaginal and urinary tissue, and in blood vessel walls — which is why the symptoms of menopause show up in so many different places at once.
Calms temperature regulation
Estrogen receptors in the hypothalamus influence the body's thermoregulatory set point. Restoring estradiol is the most effective studied approach to hot flashes and night sweats.
Supports bone density
Estrogen slows the rate at which bone is broken down. The years immediately after menopause carry the fastest bone loss of a woman's life.
Supports genitourinary tissue
Vaginal and urethral tissue is estrogen-dependent. Declining estradiol contributes to dryness, discomfort with intercourse, and urinary symptoms.
Paired with progesterone if you have a uterus
Estrogen alone stimulates the uterine lining. Anyone with an intact uterus needs progesterone alongside it for endometrial protection.
HOW PEPTRA WORKS
From intake to your door in three to seven days
Prescription medicine from board-certified physicians, shipped to your door.
Step 2
Doctor review
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*
Within 72 hours
Step 3
Fast shipping
Approved medications ship directly to your door in discreet packaging.
2-5 business days
Step 4
Unlimited messaging
Your doctor is available via chat any time for additional support. Video consults available.
Up to 12 months
Prescription medicine from board-certified physicians, shipped to your door.
*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
WHY PEPTRA MEDICINE
Precision medicine protocols to support longevity
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Proactive care
Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.
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Transparent pricing
No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.
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Board-certified doctors
Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.
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Curated by longevity experts
Every protocol is built by medical experts, based on longevity research from Our founder's science team.
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COMMON QUESTIONS
Questions, answered
What is oral estradiol?
How does oral estradiol compare to patches or creams?
Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program.