Step 1
Medical intake
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A few minutes
Once-daily low-dose tadalafil was evaluated in randomized placebo-controlled trials and improved erectile function scores compared with placebo, without requiring dosing around anticipated activity.
Tadalafil Tablets
Tadalafil Tablet (Generic for Cialis®)
$89/mo*
Duration
Strength
The same pathway as sildenafil with a much longer half-life. Taken daily at a low dose, it removes timing from the equation entirely.
Supports
Get Started
Longer-duration ED support
HSA/FSA reimbursable
No Membership Required
Licensed US Pharmacies
FDA-approved PDE5 inhibitor. Contraindicated with nitrates. Prescription only; dispensed after a medical evaluation.
Fast, discreet shipping
Unlimited follow-up with licensed physicians
Once-daily low-dose tadalafil was evaluated in randomized placebo-controlled trials and improved erectile function scores compared with placebo, without requiring dosing around anticipated activity.
TWO WAYS TO TAKE IT
One removes the timing. The other extends the window.
FDA-approved prescribing information for tadalafil tablets; Porst et al., European Urology (2006)
With treatment
Without treatment
Illustrates pharmacokinetic differences between dosing approaches. Not a comparison of branded products.
HOW TADALAFIL WORKS
Same pathway, much longer window.
Glucose control.
Like sildenafil, tadalafil inhibits PDE5, the enzyme that breaks down the cGMP produced during arousal. What separates it is duration: a half-life of roughly 17.5 hours means a single dose remains active for up to about 36 hours, and a low daily dose maintains steady levels continuously.
Inhibits PDE5
Blocking cGMP breakdown allows the arousal signal to persist long enough to produce and maintain an erection.
Daily at 5mg removes timing
A low daily dose keeps levels steady, so nothing has to be taken in advance of anything.
20mg as needed for a long window
A single higher dose covers roughly 36 hours, which is why it is sometimes described as the weekend option.
Less affected by food
Absorption is not meaningfully affected by meals, unlike sildenafil.
HOW PEPTRA WORKS
From intake to your door in three to seven days
Prescription medicine from board-certified physicians, shipped to your door.
Step 2
Doctor review
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*
Within 72 hours
Step 3
Fast shipping
Approved medications ship directly to your door in discreet packaging.
2-5 business days
Step 4
Unlimited messaging
Your doctor is available via chat any time for additional support. Video consults available.
Up to 12 months
Prescription medicine from board-certified physicians, shipped to your door.
*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
WHY PEPTRA MEDICINE
Precision medicine protocols to support longevity
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Proactive care
Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.
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Transparent pricing
No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.
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Board-certified doctors
Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.
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Curated by longevity experts
Every protocol is built by medical experts, based on longevity research from Our founder's science team.
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COMMON QUESTIONS
Questions, answered
What is tadalafil?
On demand vs. daily dosing — which is right for me?
What are the side effects?
Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program.