Step 1
Medical intake
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A few minutes
A pragmatic, double-blind randomized trial in England and Wales found that women with persistent acne treated with spironolactone reported better acne-specific quality of life scores at 24 weeks than those on placebo.
Spironolactone
Spironolactone Tablets
$99/mo*
Duration
For acne that tracks with your cycle and sits along the jaw and chin, the driver is usually hormonal rather than topical.
Supports
Get Started
Hormonal acneJawline & chin breakouts
HSA/FSA reimbursable
No Membership Required
Licensed US Pharmacies
Use of spironolactone for acne is off-label. Because of its original role as a diuretic, it can raise potassium — your provider decides whether monitoring is needed. Prescription only; dispensed after medical evaluation.
Fast, discreet shipping
Unlimited follow-up with licensed physicians
A pragmatic, double-blind randomized trial in England and Wales found that women with persistent acne treated with spironolactone reported better acne-specific quality of life scores at 24 weeks than those on placebo.
HORMONAL ACNE
Jawline, chin, and cycle-timed. That pattern has a cause.
Santer et al., SAFA, BMJ (2023)
Spironolactone
Placebo
Trial data in adult women with persistent acne. Use of spironolactone for acne is off-label.
HOW SPIRONOLACTONE WORKS
Turns down the hormonal signal to the oil glands.
Glucose control.
Spironolactone was developed as a potassium-sparing diuretic, but it also binds androgen receptors without activating them. In skin, that blocks the androgen signal that drives sebaceous glands to produce oil — which is why it is used for hormonally driven acne, unwanted hair growth, and androgenetic hair loss in women.
Blocks androgen receptors in skin
Occupying the receptor without activating it reduces the androgen signal reaching sebaceous glands and hair follicles.
Reduces sebum production
Less oil means fewer clogged follicles, which addresses hormonal acne closer to its source than topical treatment does.
Works on a months timeline
Meaningful change is generally assessed at three to six months. The SAFA trial found the gap over placebo continued widening through 24 weeks.
Requires potassium awareness
Because of its original role as a diuretic, spironolactone can raise potassium. Your provider decides whether monitoring is needed based on your age and health history.
HOW PEPTRA WORKS
From intake to your door in three to seven days
Prescription medicine from board-certified physicians, shipped to your door.
Step 2
Doctor review
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*
Within 72 hours
Step 3
Fast shipping
Approved medications ship directly to your door in discreet packaging.
2-5 business days
Step 4
Unlimited messaging
Your doctor is available via chat any time for additional support. Video consults available.
Up to 12 months
Prescription medicine from board-certified physicians, shipped to your door.
*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
WHY PEPTRA MEDICINE
Precision medicine protocols to support longevity
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Proactive care
Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.
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Transparent pricing
No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.
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Board-certified doctors
Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.
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Curated by longevity experts
Every protocol is built by medical experts, based on longevity research from Our founder's science team.
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COMMON QUESTIONS
Questions, answered
Is spironolactone FDA-approved for acne?
How long until it works?
Does it require monitoring?
Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program.