Step 1
Medical intake
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A few minutes
In a randomized crossover trial in fibromyalgia, participants reported greater reduction in pain during the low-dose naltrexone period than during placebo, in a study the authors themselves describe as small and preliminary.
Naltrexone HCL Tablets
Low-Dose Naltrexone HCL Tablets
$79/mo*
Duration
At about a tenth of the standard dose, naltrexone behaves differently — briefly occupying opioid receptors and dampening immune signaling in the central nervous system.
Supports
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Inflammation supportWeight managementImmune modulation
HSA/FSA reimbursable
No Membership Required
Licensed US Pharmacies
Low-dose naltrexone is prescribed off-label for these uses. Dispensed on prescription following a medical evaluation.
Fast, discreet shipping
Unlimited follow-up with licensed physicians
In a randomized crossover trial in fibromyalgia, participants reported greater reduction in pain during the low-dose naltrexone period than during placebo, in a study the authors themselves describe as small and preliminary.
DOSE CHANGES THE DRUG
50mg blocks receptors. 4.5mg taps them.
Younger, Parkitny & McLain, Clinical Rheumatology (2014)
4.5mg
50mg
Illustrative of the pharmacologic difference between doses. The rebound mechanism is hypothesized and under study.
HOW LDN WORKS
A brief block, then a rebound.
Glucose control.
Naltrexone is an opioid receptor antagonist. At 4.5mg it occupies those receptors only briefly, and the leading hypothesis is that the body responds by increasing its own endorphin production. A separate proposed pathway involves reduced inflammatory signaling from glial cells in the central nervous system.
Brief receptor occupancy
The low dose clears quickly, producing a short window of partial blockade rather than the sustained blockade seen at 50mg.
Proposed endorphin upregulation
The working hypothesis is that transient blockade prompts a compensatory increase in endogenous endorphin production after the drug clears.
Proposed glial modulation
Research has examined whether LDN reduces microglial inflammatory signaling via toll-like receptor 4. This remains a hypothesis under study.
Taken at night, titrated up
LDN is typically started low and increased over several weeks. Vivid dreams and sleep disturbance early on are the most commonly reported effects.
HOW PEPTRA WORKS
From intake to your door in three to seven days
Prescription medicine from board-certified physicians, shipped to your door.
Step 2
Doctor review
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*
Within 72 hours
Step 3
Fast shipping
Approved medications ship directly to your door in discreet packaging.
2-5 business days
Step 4
Unlimited messaging
Your doctor is available via chat any time for additional support. Video consults available.
Up to 12 months
Prescription medicine from board-certified physicians, shipped to your door.
*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
WHY PEPTRA MEDICINE
Precision medicine protocols to support longevity
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Proactive care
Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.
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Transparent pricing
No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.
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Board-certified doctors
Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.
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Curated by longevity experts
Every protocol is built by medical experts, based on longevity research from Our founder's science team.
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COMMON QUESTIONS
Questions, answered
What is low-dose naltrexone (LDN)?
How is naltrexone typically taken?
What are the side effects?
Who should not take naltrexone?
Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program.