In men whose gonadotropins were suppressed by testosterone, low-dose hCG maintained intratesticular testosterone in a dose-dependent manner — the testes stayed active despite the external supply.

  • Prescription Only
  • Injectable

HCG (Human Chorionic Gonadotropin)

Human Chorionic Gonadotropin Injection

$349/mo*

Duration

HCG mimics luteinizing hormone, the signal that tells the testes to produce testosterone. It is most often used alongside or after testosterone therapy to keep that pathway active.

Supports
Testicular activityFertility-conscious protocolsTRT support
Get Started
HSA/FSA reimbursable

HSA/FSA reimbursable

No Membership Required

No Membership Required

Licensed US Pharmacies

Licensed US Pharmacies

HCG is not approved for weight loss. Requires monitoring; estradiol can rise on hCG. Prescription only; dispensed after medical evaluation.

Fast, discreet shipping

Unlimited follow-up with licensed physicians

In men whose gonadotropins were suppressed by testosterone, low-dose hCG maintained intratesticular testosterone in a dose-dependent manner — the testes stayed active despite the external supply.

WHAT TRT SUPPRESSES

Testosterone therapy replaces the hormone. It doesn't replace the signal.

Coviello et al., Journal of Clinical Endocrinology & Metabolism (2005)

With treatment Without treatment
Trial data in men with testosterone-induced gonadotropin suppression. HCG is not approved for weight loss.

HOW HCG WORKS

Keeps the testes receiving a signal.

Glucose control.

HCG is structurally similar to luteinizing hormone and binds the same receptor on the Leydig cells of the testes. That makes it a way to stimulate testicular testosterone production directly, independent of whether the pituitary is still sending its own signal.

Acts as an LH analog

HCG binds the LH receptor in the testes, prompting the same downstream testosterone production the pituitary signal would trigger.

Maintains testicular activity on TRT

Because external testosterone suppresses the pituitary signal, hCG is often added to keep intratesticular testosterone and testicular volume from declining.

Used in fertility-conscious protocols

Men who want to preserve sperm production while on testosterone therapy, or who are planning to come off it, are the typical candidates.

Requires monitoring

Estradiol can rise on hCG. Bloodwork is part of the protocol, not optional.

HOW PEPTRA WORKS

From intake to your door in three to seven days

Prescription medicine from board-certified physicians, shipped to your door.

Medical intake

Step 1

Medical intake

Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.

A few minutes
Doctor review

Step 2

Doctor review

A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*

Within 72 hours
Fast shipping

Step 3

Fast shipping

Approved medications ship directly to your door in discreet packaging.

2-5 business days
Unlimited messaging

Step 4

Unlimited messaging

Your doctor is available via chat any time for additional support. Video consults available.

Up to 12 months

Prescription medicine from board-certified physicians, shipped to your door.

*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.

WHY PEPTRA MEDICINE

Precision medicine protocols to support longevity

  • Proactive care

    Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.

  • Transparent pricing

    No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.

  • Board-certified doctors

    Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.

  • Curated by longevity experts

    Every protocol is built by medical experts, based on longevity research from Our founder's science team.

Explore other treatments

NAD+ Injection

NAD+ is a coenzyme every cell uses to convert food into usable...

NAD+ Nasal Spray

The same coenzyme as the injection, delivered as a nasal spray. Needle-free...

Sermorelin

A growth hormone releasing hormone analog. Rather than supplying growth hormone directly,...

Estradiol Cream

Estradiol applied to the skin instead of swallowed. Absorbing through the skin...

Semaglutide Injection

A GLP-1 receptor agonist that supports appetite regulation and slows gastric emptying....

Tirzepatide Injection

A dual agonist that activates two gut hormone receptors rather than one....

Browse All

View our full collection

COMMON QUESTIONS

Questions, answered

What is HCG used for here?

It mimics luteinizing hormone to keep the testes active, most often alongside or after testosterone therapy.

Is HCG for weight loss?

No. HCG is not approved or used here for weight loss — this listing is specifically for testicular/fertility support alongside TRT.

Does it require monitoring?

Yes — estradiol can rise on hCG, so bloodwork is part of the protocol.

Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program.